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Acetaminophen, butalbital, and caffeine are excreted into human milk in small concentrations. The significance of the effects on nursing infants has not been reported, but due to the potential for serious adverse reactions in nursing infants, other agents may be preferred.
A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Excreted into human milk: Yes (acetaminophen); Yes (barbiturates); Yes (caffeine)
Using Fioricet during pregnancy is recommended only if the benefits to the mother greatly outweigh the risks to the fetus.
Actually we do not suggest you take fioricet while you are pregnant. All three components of Fioricet can pass through the uterus, and the drug may cause abnormalities. The lowest risk strategy is to avoid taking this medication when pregnant.
Animal reproduction studies have not been conducted on this combination product. Epidemiologic data for acetaminophen, including a population based case-control study from the National Birth Defects Prevention Study (n= 11,610) and data from 26,424 live singleton births have shown no increased risk of major birth defects in children with first trimester prenatal exposure.
In 2015, the US Food and Drug Administration released results of their evaluation on published research studies looking at mothers who took acetaminophen (either over the counter or as a prescription product) at any time during their pregnancy and the risk of attention deficit hyperactivity (ADHD) in their babies.
They found all studies reviewed had potential limitations in their designs that prevented drawing reliable conclusions. Barbiturates have been reported to readily cross the placental barrier. A 2-day old infant whose mother had taken a butalbital-containing product during the last two months of pregnancy experienced withdrawal seizures; butalbital was found in the infant’s serum. There are no controlled data in human pregnancy.
US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Drug components of Fioricet can also be passed to the infant while breastfeeding and can accumulate in their body. The effects can be dangerous, and Fioricet should also be avoided while breastfeeding if possible.
Fioricet is prescribed primarily for tension headaches, but can also be used for migraines or managing fever and pain in combination. Generally, Fioricet is used when over-the-counter medications have failed to adequately manage headache pain.
Following an acute overdosage of butalbital, acetaminophen and caffeine, toxicity may result from the barbiturate or the acetaminophen. Toxicity due to caffeine is less likely, due to the relatively small amounts in this formulation.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Fioricet can be fatal.
The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Overdose symptoms may also include insomnia, restlessness, tremor, diarrhea, increased shallow breathing, uneven heartbeats, seizure (convulsions), or fainting.
While butalbital is the addictive ingredient in Fioricet, acetaminophen is the ingredient which is liable to cause an overdose. Unfortunately, people who misuse Fioricet as a recreational drug or as a way to suppress withdrawal are most likely to suffer an overdose.
When a person overdoses on Fioricet, the acetaminophen will damage their liver. In severe cases, an overdose can even provoke fatal liver failure. For this reason, it is dangerous to take Fioricet together with another medication which contains acetaminophen because it increases the risk of overdose and death. Furthermore, drinking alcohol while taking Fioricet may also inflict liver damage.
A Fioricet overdose is a medical emergency, so it’s important to know the symptoms. An overdose on Fioricet and all other forms of liver failure cause jaundice, the yellowing of the skin and eyes. Other symptoms of an overdose include:
A single or multiple drug overdose with this combination product is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption.
Oxygen, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated. Assisted or controlled ventilation should also be considered.
Gastric decontamination with activated charcoal should be administered just prior to N-acetylcysteine (NAC) to decrease systemic absorption if acetaminophen ingestion is known or suspected to have occurred within a few hours of presentation. Serum acetaminophen levels should be obtained immediately if the patient presents 4 hours or more after ingestion to assess potential risk of hepatotoxicity; acetaminophen levels drawn less than 4 hours post-ingestion may be misleading. To obtain the best possible outcome, NAC should be administered as soon as possible where impending or evolving liver injury is suspected. Intravenous NAC may be administered when circumstances preclude oral administration.
Vigorous supportive therapy is required in severe intoxication. Procedures to limit the continuing absorption of the drug must be readily performed since the hepatic injury is dose dependent and occurs early in the course of intoxication.
This product is contraindicated under the following conditions:
This combination drug product is intended as a treatment for tension headache.
It consists of a fixed combination of butalbital, acetaminophen and caffeine. The role each component plays in the relief of the complex of symptoms known as tension headache is incompletely understood.
The behavior of the individual components is described below.
Butalbital is well absorbed from the gastrointestinal tract and is expected to distribute to most tissues in the body. Barbiturates in general may appear in breast milk and readily cross the placental barrier. They are bound to plasma and tissue proteins to a varying degree and binding increases directly as a function of lipid solubility.
Elimination of butalbital is primarily via the kidney (59% to 88% of the dose) as unchanged drug or metabolites. The plasma half-life is about 35 hours. Urinary excretion products include parent drug (about 3.6% of the dose), 5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5 (3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8% of the dose), products with the barbituric acid ring hydrolyzed with excretion of urea (about 14% of the dose), as well as unidentified materials. Of the material excreted in the urine, 32% is conjugated.
The in vitro plasma protein binding of butalbital is 45% over the concentration range of 0.5 to 20 mcg/mL. This falls within the range of plasma protein binding (20% to 45%) reported with other barbiturates such as phenobarbital, pentobarbital, and secobarbital sodium. The plasma-to-blood concentration ratio was almost unity, indicating that there is no preferential distribution of butalbital into either plasma or blood cells (See OVERDOSAGE for toxicity information).
Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug. (See OVERDOSAGE for toxicity information).
Like most xanthines, caffeine is rapidly absorbed and distributed in all body tissues and fluids, including the CNS, fetal tissues, and breast milk.
Caffeine is cleared through metabolism and excretion in the urine. The plasma half-life is about 3 hours. Hepatic biotransformation prior to excretion, results in about equal amounts of 1-methylxanthine and 1-methyluric acid. Of the 70% of the dose that is recovered in the urine, only 3% is unchanged drug. (See OVERDOSAGE for toxicity information).
This product may impair mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. Such tasks should be avoided while taking this product.
Alcohol and other CNS depressants may produce an additive CNS depression, when taken with this combination product, and should be avoided.
Butalbital may be habit-forming. Patients should take the drug only for as long as it is prescribed, in the amounts prescribed, and no more frequently than prescribed.
Barbiturates may be habit-forming: Tolerance, psychological dependence, and physical dependence may occur especially following prolonged use of high doses of barbiturates. The average daily dose for the barbiturate addict is usually about 1500 mg.
As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two-fold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller. The lethal dose of a barbiturate is far less if alcohol is also ingested.
Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs. Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days.
Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug. Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens. One method involves initiating treatment at the patient’s regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.
Fioricet is used to treat migraine and various forms of headache. Many doctors prescribe it to their patients because it is a sedative and a pain killer wrapped in one. When you have a prescription, you can buy Fioricet anywhere, but you should know that you should not exceed dosage prescribed by your doctor. However, if you have exceeded the dosage, you should call your doctor and tell him what side effects you are experiencing so he can help you out.
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When you order Fioricet , you will get it in form of pills for oral usage of various shapes and colors. Usually it’s made in white or blue color, and the shape might be round or oval. Dosage is same for any of mentioned, 40mg, only shapes and colors are different.
Tell your doctor your medical history, especially of: serious liver disease, alcohol or narcotic dependence, emotional/mental conditions, heart disease (arrhythmias, recent MI), stomach/intestinal ulcers, any allergies. Acetaminophen may cause liver damage. Daily use of alcohol, especially when combined with acetaminophen, may increase your risk for liver damage.
Check with your doctor or pharmacist for more information. To prevent oversedation, avoid using alcohol and other sedative type medications while taking this. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Avoid alcoholic beverages.
This medication contains caffeine. Avoid drinking large amounts of caffeinated beverages while taking this medication as excessive nervousness and irritability can occur. This medication should be used during pregnancy only if clearly needed. Small amounts of this medication appear in breast milk. Consult your doctor before breast-feeding.
Doctors usually prescribe one pill of Fioricet to be taken on every four hours. You should not exceed six pills per day. You should not take Fioricet if you are using beta-blockers, because it can reduce or even negate their effect. At the start of treatment, you might feel drowsy, but the effects will disappear as time passes. You might encounter some side effects while on Fioricet treatment, including shaking / tremors, abdominal pain, vomiting, anxiousness and nausea. If you do encounter any of mentioned, you should contact your doctor so you can receive suitable replacement. If Fioricet is prescribed by doctor who knows your full medical history, side effects can be lowered to minimum or may never appear. Consequences of overdosing can be very serious, even fatal. You should not buy Fioricet if you are abusing alcohol or drugs.
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Fioricet is a prescription drug which is used in treatment of headaches. It is actually a combination drug which combines three ingredients that work together and provide a relief of headache pain in tensions headaches, muscle contraction headaches and headaches that occur after post-dural puncture.
The first ingredient in Fioricet is butalbital. This is a barbiturate drug which is very rarely used alone but which has found its way into a number of combination drugs, including Fioricet. Since it is a barbiturate drug, it is a relatively potent analgesic, meaning that it provides relief from pain. It can also be dependency-forming, but in Fioricet it is not present in such large doses so as to cause dependency unless it is used improperly or for too long.
The second ingredient in Fioricet is acetaminophen, also known as paracetamol. It is one of the most basic and most common drugs in the world. It is also a painkiller which can be used to treat mild to moderate pain. On its own, it can be used in treatment of headaches and it is only logical that it was included in Fioricet. It can cause liver damage if it is used improperly and it is often included in medications to discourage overuse.
The third ingredient in Fioricet is a formulation of caffeine which is a common stimulant present in coffee and tea. It is used in Fioricet for two reasons. The first is that it can enhance the effects of the other two ingredients that provide the majority of analgesic effects and the second one is that it has been found to constrict blood vessels, especially in the brain. This can also provide substantial relief from pain that is associated with tension headaches.
Fioricet was developed specifically with headaches in mind. It has found other uses, however, although these uses are still considered off-label and investigational. For example, Fioricet is sometimes used in treatment of migraines and there are a lot of people for whom it has done wonders when their migraines are in question. Some people take Fioricet for back pain and other painful conditions. These are not common uses for this drug but we felt that we should mention them as well.
Fioricet is a relatively potent medication and it should be taken with utmost care. It is usually not the first line treatment for headaches due to its potency and the fact that it contains a barbiturate drug. It is used when less potent drugs have failed and/or when the pain is extremely severe.
Using Fioricet without your doctor recommending it is something that we would not advise and something that can be dangerous for some people. Also, using the drug improperly, for periods of time that are longer than recommended or in amounts larger than the recommended one can lead to adverse effects and serious dangerous effects on the health.
It should also be pointed out that the Fioricet formulation has changed. The old formulation included 50 mg of butalbital, 325 mg of acetaminophen and 40 mg a caffeine in the tablet. The new formulation is in form of capsules and it contains 50 mg of butalbital, 300 mg of acetaminophen and 40 mg of caffeine. As you can see, the amount of acetaminophen has been reduced due to new FDA guidelines concerning the limitation of acetaminophen amounts in combination drugs.
Fioricet is available online at various online pharmacies where you can order it and have them deliver the drug to your address. For many parts of the world, it is possible to have overnight delivery while there are parts where you will have to wait. The prices are lower online and when you find a reputable online pharmacy, you can safely and cheaply order Fioricet.
Tell your doctor of all prescription and nonprescription drugs you may use, especially of: “blood thinners” Tell your doctor or pharmacist of all prescription and nonprescription drugs you may use that cause drowsiness such as: medicine for sleep (e.g., sedatives), tranquilizers, anti-anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine). Because this medication contains acetaminophen, check with your doctor or pharmacist before taking other medications containing acetaminophen which is commonly found in nonprescription pain relievers and cough-and-cold products. Read labels carefully to check ingredients. This drug may interfere with the effectiveness of birth control pills. Discuss using other methods of birth control with your doctor. Do not start or stop any medicine without doctor or pharmacist approval.
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If you suffer from chronic headaches, you are well aware of the disruption this can cause in your daily life. Trying to work or socialize while experiencing a headache can be quite difficult. Migraines can make these activities virtually impossible.
The majority of those suffering from chronic headaches report that they are unable to lead a normal life. Migraine and tension headaches disrupt their work, social, and family life.
A single debilitating headache can steal many valuable hours away from a day. After unsuccessfully trying several of the headache medications available, some chronic sufferers may simply give up. Before doing this, they might want to try Fioricet. It may just be the answer they have been seeking.
Fioricet can easily be bought online or at your local pharmacy, but you will need to obtain a prescription from a physician first. Most doctors are aware of the benefits of Fioricet and will readily provide a prescription for those suffering from migraines and tension headaches.
The three active ingredients in Fioricet work together to relieve migraines and tension headaches. Fioricet is unique in that it includes acetaminophen, butalbital, and caffeine. While acetaminophen may be found in over the counter medicines, its combination with the other two ingredients is what makes Fioricet truly effective.
Butalbital is a barbiturate, which creates a sense of relaxation in the body. Caffeine further alleviates tension headaches by reducing the flow of blood to the brain. The combination of these three ingredients have provided immense relief to many chronic headache sufferers.
Fioricet comes in capsule and tablet form and is usually taken every four hours as needed. It is advised not to take more than six capsules in a day. Be sure to follow your doctor’s instructions carefully. If you feel that you are in need of a larger dose, consult your doctor first.
The butalbital in Fioricet tends to make people drowsy. It is important to stay away from driving or using heavy machinery after a dose. As with any medication, take care when using Fioricet. With the assistance of your physician, Fioricet can be taken safely, often with excellent results.
If you are interested in learning more about Fioricet, your doctor or pharmacist will be able to answer any questions or concerns you may have. Your physician will determine if Fioricet is a viable solution for your chronic headaches.
Each year, there is an estimated eight million people seeking consultation with their physician in an attempt to alleviate headache pain. About 45 million Americans experience chronic headaches. The majority of these people turn to over-the-counter medication to relieve their headaches. For severe tension and migraine headaches, these medications often do not do the trick. Before giving up altogether on headache relief, you might try Fioricet medication first.
Fioricet is an exceptional headache medication because it combines three ingredients which, when combined, offer an incredible source of headache relief. These three active ingredients are butalbital, acetaminophen, and caffeine. Butalbital is a barbiturate, which is know to create a feeling of relaxation within the body. Acetaminophen increases the body’s pain threshold. Everyone is familiar with caffeine and many of us take in caffeine daily through coffee, tea, or soda. It works to reduce blood vessels back to their normal size. This greatly reduces the risk of nerve aggravation caused by swollen blood vessels. The benefits of these three drugs are augmented when combined with one another. This is why Fioricet often works when other medications fail to ease headache pain. Most over-the-counter medications just aren’t strong enough to deal with severe tension and migraine headaches.
Fioricet medication is easy to purchase online or from a pharmacy. A prescription is necessary and can easily be obtained from your doctor or through a licensed online pharmacy. Such a pharmacy will need to have a doctor on board who will be able to provide a prescription.
A doctor will have the ability to answer any questions or concerns you may have about Fioricet. They will be able to determine whether or not Fioricet is a safe option for you, and will provide additional instructions on the administration of this medication. Typically, one tablet of Fioricet is to be taken every four hours as needed. It is advised not to take more than six tablets in one day. The barbiturate in this medication has a tendency to cause drowsiness. It is important to avoid driving or using heavy machinery while taking Fioricet. This medication can provide excellent headache relief and is safe to take as long as directions are carefully followed.
Fioricet medication will help you to sit back and relax while your headache tension is released. It is likely to help you get on with your daily life.
